Optimal Control of Anti-Angiogenesis and Radiation Treatments for Cancerous Tumor: Hybrid Indirect Solver

This paper proposes a real-life volume reduction for cancer cells using optimal doses of radiation and an anti-angiogenic drug. A generalized dynamical system based on the diffusion-consumption equation along with stimulation inhibition factors is proposed. To achieve continuous low-dose therapy, related problem simulated by regulator mathematically. By combining steepest descent, conjugate gradient, Armijo techniques, novel hybrid indirect iterative solver designed. For accuracy execution speed, current compared interior-point optimizer sequential quadratic Hamiltonian methods. Cancer therapy under two different treatment strategies 24 various versions general considered numerically. comprehensive analysis corresponding outcomes presented. Numerical results diagrams are provided.